Warfarin Induces Cardiovascular Damage in Mice

Warfarin induces cardiovascular damage in mice.

OBJECTIVE Vascular calcification is an independent risk factor for cardiovascular disease. Once thought to be a passive process, vascular calcification is now known to be actively prevented by proteins acting systemically (fetuin-A) or locally (matrix Gla protein). Warfarin is a vitamin K antagonist, widely prescribed to reduce coagulation by inhibiting vitamin K-dependent coagulation factors. ...

Neutrophil-Mediated Organ Damage in Mice Human Lupus Serum Induces

Ionizing radiation induces ferroptosis in splenic lymphocytes of mice

Backgrounds: It remains unclear whether radiation-induced haemorrhage in the spleen causes iron accumulation, and subsequently, ferroptosis in splenic lymphocytes. In this study, we investigated the occurrence of ferroptosis in splenic lymphocytes of gamma-irradiated mice. Materials and Methods: Mice were subjected to gamma radiation from a 137Cs source. Iron, Ferroportin 1, and iron regulatory...

Survey of Cardiovascular Damage due to Atherosclerosis in 112 Patients

ABSTRACT Atherosclerosis is one of the most common disorders in Iran. It usually involved adult males over the age of 60 year. All Major and middle arteries are at risk and usually it has two types effects on arteries, Occlusive lesions in the site of dividing arteries and aneurysmal lesions which occure in abdominal aorta in 90%. Frequency, symptoms and pathologies of atherosclosis is still...

Effect of VKORC1 Gene Polymorphism on Warfarin Response in Razavi Khorasan Province Cardiovascular Patients

Background and Aims: Warfarin is an anticoagulant agent used for many years in treating various clinical conditions such as thromboembolisms in cardiovascular disease. Some patients require different doses of warfarin to reach the therapeutic international normalized ratio ratio. These patients have specific demographic characteristics. Genetic polymorphisms in specific genes have been reported...